Association of Inflammation Genes with Prostate Cancer
نویسندگان
چکیده
Erika M. Kwon, Claudia A. Salinas, Suzanne Kolb, Rong Fu, Ziding Feng , Janet L. Stanford , and Elaine A. Ostrander National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Building 50, 50 South Drive, Bethesda, MD 20892, USA Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1124 Fairview Ave N., Seattle, WA 98103, USA Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
منابع مشابه
ژنتیک مولکولی، تشخیص، پیشگیری و ژن درمانی در سرطان پروستات: مقاله مروری
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leading cause of cancer death (after lung cancer) among men. The several studies have been shown prostate cancer familial aggregation. The main reason for this aggregation is inheritance included genes....
متن کاملAssociation Study of miR-124-a-3 Gene rs34059726 Polymorphism with Prostate Cancer in Gonbad Kavous
Background: MiRNAs are one of the most important genetic regulators that regulate more than 50 percent of the human genome. MiR-124-a-3 is a tumor suppressor miRNA which its expression dramatically reduced in prostate cancer tumor cells. Since miRNA binding to the transcript of target genes by seed sequence, any mutations and changes in this region could be effective on its performance and iden...
متن کاملThe impact of BMI, Smoking, Family History and Ala 119 Ser (rs1056827) Polymorphism of CYP1B1*2 Genes with Susceptibility to Prostate Cancer among Iranian Men
Background and Aims: The genes involved in detoxification and the elimination of toxic metabolites have a vital role in cancer pathogenesis. Also, there is evidence that higher amounts of body fat are associated with increased risks of several cancers. The current study aims to identify the relationship of age, body mass index (BMI), smoking, family history, and polymorphism rs1056827 of CYP1B1...
متن کاملNon – Detection of HPV DNA in Prostatic Cancer and Benign Prostatic Hyperplasia: a case- control study in Kerman
Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than 100 types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-16 and HPV-18 have shown further association with cancer. Regarding the pr...
متن کاملبررسی نقش ژن CYP1B1 در سرطان پروستات در دو جمعیت ایرانی و هندی
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer death among men in the world. Growth, maintenance and the expression of genes involved in the production of steroids, may alter the susceptibility of prostate cancer. One such gene, CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1) is involved in the activation of many carcinogens and i...
متن کاملProstate Cancer with Intraluminal Inclusions: the Association of the Immunophenotype with Grade Score
Background & Objective: To study the immunophenotype of prostate cancer (PC) with the presence and absence of intraluminal inclusions (IIn), depending on the grade score. Methods: A total of 30 PC samples with IIn (group E) and 30 PC samples without them (group C) were studied. These groups were divided into 2 subgroups, depending on the grade of malignan...
متن کامل